Duncan Robinson scored 19 points and Moritz Wagner added 18 to help No. 17 MI beat Penn State 72-63 on Wednesday night.
Wagner led the Wolverines in scoring with 20 points at Northwestern and poured in 20 more at Wisconsin, which marked just the second time all season he recorded back-to-back 20-point performances.
With the victory, MI remains No. 4 in the Big Ten Standings while Penn State is at No.6.
As a freshman, the 6-foot-9, 254-pound Watkins had 18 points, 11 rebounds and eight blocked shots as Penn State ended Nebraska's season in last year's Big Ten Tournament.
Robinson continued to be huge off the bench, scoring a team-high 19 points.
The loss is a massive one for Penn State (19-11, 9-8 Big Ten). Nebraska would build up a lead, Penn State would score a rapid succession of buckets to bring things to within in one, but then falter and allow the Cornhuskers to stretch their lead out.
MI used an 18-7 run to open up a double-digit lead late in the first half. Yet, in a place that hasn't always been kind to MI basketball, the Wolverines scored a huge road win.
MI wasn't as effective in turning points into turnovers - 9 points from turnovers, compared to Penn State's 14.
Jaaron Simmons was the first point guard off the bench but Eli Brooks, a Spring Grove, Pennsylvania native, saw action for the first time since February 6, and quickly converted a nifty layup.
The Nittany Lions played hard to stay afloat through the high-octane performances of Tony Carr and Lamar Stevens who scored 21 and 19 points respectively. Carr's 3-pointer with 51 seconds left cut Penn State's deficit to six.
Ty Jerome scored 18 points for the Cavaliers (25-2, 14-1), who also got nine points each from De'Andre Hunter and Mamadi Diakite. MI shot 52 percent, 50 from three-point range, to PSU's 39.3 and 28.6. Watkins did not return from the locker room following halftime. It was her 20 rebounds and three blocks that helped give the Cornhuskers the edge over the Lady Lions on the night both on the scoreboard and the backboard, with a 60-31 Nebraska lead in rebounds.
Having won six of eight, including two upset wins over Ohio State and a near road win over Purdue, Penn State was playing their best basketball of the season. Matthews played just 17 minutes.