Even the departure of playmaker Philippe Coutinho to Barcelona in January could not derail Liverpool, as Jurgen Klopp's side battle to finish second in the Premier League and make progress in Europe.
Merseyside supporters will be hoping that history repeats itself as there is more than enough quality in this Liverpool side to hurt Manchester United in a big way.
"It will not be easy but I've always said we can beat any team in the world", said Mane, as quoted by Sky Sports.
As you would expect though, as an ex-Manchester United player, Gary Neville is still hypercritical of Liverpool and is not giving the Reds an edge this weekend. "I also missed an easy chance in that game, but he is great", Salah told Sky Sports.
There was a palpable sensation around Anfield on Tuesday that Liverpool minds were already focused on United, with the free-scoring front three all rested at different spells of the game. "How strong he goes in both remains to be seen". I said, "for me, the team is the most important thing". Manchester City are the only team over the last couple of years.
"Of course they have a good squad and we have respect for them, but we don't fear anyone".
GETTY Gary Neville has warned Jose Mourinho about his tactics
Matic's ability to take on responsibility and remain disciplined for the sake of the team is something Mourinho will demand in new additions, with the board totally behind his plans.
Mourinho conceded recently "to play Liverpool has a special meaning" for United, so reserving his stars' energies for midweek is out of the question.
"I enjoy playing against big, top strikers", Lovren said.
With Pep Guardiola's Manchester City virtually assured of the title, northwest rivals United and Liverpool - the two most successful clubs in the English game - are left fighting for the scraps.
"I try to look for a goal in any game I play".