In a separate statement, Le Drian called upon the global community to take action to prevent Iranian missiles from becoming a threat to "all regional actors".
"Those who for 70 years have been fomenting chaos, war and destruction in the region and have committed genocide and caused the Sabra and Shatila [massacres], are not in a position to talk about Iran's threat", Rouhani said.
Last week, France's foreign minister said he believed Iran needed to address Europe's demands over its ballistic missile program or risk new sanctions.
He emphasized that the Islamic Republic's power will always be in service of strengthening those countries in need.
The US Nuclear Posture Review reflects greater reliance on nukes in violation of the #NPT, bringing humankind closer to annihilation.
Despite French leaders' criticism over the missile program, French companies, including oil giant Total SA, have entered into deals with Iranian companies.
He stressed that all Iranian parties agree on the continuation of missile capabilities, noting that "some disagreements among the political groups do not prevent defending the national interests; and the defense and missile capabilities is one of them". He added that Iran's missiles "are defensive and are not created to carry weapons of mass destruction, since we don't have any".
Rouhani welcomed France's efforts to preserve the 2015 nuclear deal, which the United States has threatened to tear up. However, the historic agreement did not touch upon missile development, and efforts by the United States and its European allies to use the deal to force greater concessions from Tehran have greatly frustrated Iran.
"We do not know in which language and tone we say that we do not want to negotiate the missile program and defense capabilities", Hosseini said in response to the French insistence.
"They think that these methods can open the door to negotiations on other issues after the nuclear agreement".
Le Drian said there was "still a lot of work to do" on Iran's missile program after meeting with top officials, including President Hassan Rouhani and Foreign Minister Mohammad Javad Zarif.