Mattis and Dunford spoke at the Pentagon roughly an hour after Trump announced that the US, in concert with France and the United Kingdom, had launched "precision strikes" on Syria in retaliation for last weekend's chemical attacks.
He added that lawmakers would be notified before any strikes against Syrian weapons facilities and airfields to punish President Bashar Assad's suspected use of chemical weapons over the weekend.
The defence secretary says Friday's strikes have "sent a clear message" to Assad and his "murderous lieutenants". In conducting these strikes, we have gone to great lengths to avoid civilian and foreign casualties.
Last week, Trump said he wanted to pull out of the war-torn nation, but this week he has taunted Assad ally Russian Federation with boasts of an impending missile strike. Trump's ambassador to the United Nations, Nikki Haley, told NBC News on Thursday the administration has "enough proof" of the chemical attack but was still considering its response. "Never said when an attack on Syria would take place", he tweeted.
"Important infrastructure was destroyed, which will result in a setback for the Syrian regime - and they will lose years of research and development data, specialized equipment and expensive chemical-weapons precursors", Dunford said.
Trump indicated the strikes would continue until the Syrian regime's use of chemical weapons ends.
Trump could be offering prayers for the Middle East and for the US.
At stake in Syria is the potential for confrontation, if not outright conflict, between the United States and Russian Federation, former Cold War foes whose relations have deteriorated in recent years over Moscow's intervention in Ukraine, its interference in the 2016 U.S. presidential election and its support for Syrian President Bashar Assad.
But Trump says America does not seek "an indefinite presence" in Syria and will look to pull out its troops once the Islamic State is totally defeated.
The defense secretary says the airstrikes were launched against several sites that he says helped provide Assad's ability to create chemical weapons.
Trump spoke from the White House Friday night.
Mr. Mattis said he is "absolutely confident" that Mr. Assad used chemical weapons on his own people, killing dozens last week in Douma, a rebel-held suburb of Damascus.
Following the strike, reports of a retaliatory actions emerged. "And of course the powers that have signed the chemical weapons prohibition have every reason to challenge Assad should he choose to violate that".
That's according to a source familiar with the president's plans, who was not authorized to speak publicly. Trump said Thursday on Twitter.
A highly placed Russian politician is likening President Donald Trump to Adolf Hitler after the launch of airstrikes against Syria, and says he regards the action as a move against Russia.
The presence of Russian troops and air defenses in Syria had been amongst fairly just a few points weighing on Trump, who ought to moreover consider the hazards to roughly 2,000 American troops inside the nation if Russia had been to retaliate for US strikes.