Ramaphosa spoke at various engagements in London including the Commonwealth Business Forum's African Leaders' Roundtable, a working lunch with senior worldwide investors and business leaders hosted by Bloomberg and the Commonwealth Business Forum Heads of Government Roundtable with senior Business leaders.
Protesters seeking jobs, better housing, roads and hospitals frequently clash with police in a country faced with weak economic growth and near-record unemployment - but these are the first big demonstrations since Ramaphosa took power in February.
The President was in the United Kingdom to rally investors to invest in South Africa in a bid to boost the country's economy.
In addition to his plea to protesters, the President has also called on law enforcement agencies to exercise maximum restraint in execution of their duties to return calm and normality to the province. At least 23 people were arrested and one man was reported to have died in sporadic violence that erupted this week in Mahikeng, the provincial capital.
There haven't been fatalities linked with the protests, provincial police spokesman Sabata Mokgwabone said by phone.
The border to neighbouring Botswana was closed due to the violence, according to Botswanan officials, while schools, shops, offices and government services across North West province were shut on Friday.
"More than 20 years ago, Nelson Mandela asked me to come to attend the Commonwealth Business Forum and today I am overjoyed once again to be here and the privilege and the honour is doubly enhanced because this year we celebrate 100 years since Nelson Mandela's birth", he said, according to Polity.
The president was locked in a meeting with the party's provincial leaders and alliance partners last night in a bid to resolve the issues at hand.
Ramaphosa, who took over as leader of the ruling African National Congress in December, replaced Jacob Zuma as national president earlier this year.
Unemployment is at a record high of about 28 per cent, with youth unemployment reaching over 50 per cent in many areas.