Syrian television reported that Syria's air defenses, which are substantial, have responded to the attack.
"The Syrian Arab Republic condemns in the strongest terms the brutal American-British-French aggression against Syria, which constitutes a flagrant violation of worldwide law", the foreign ministry said.
Iran warned of "regional consequences" on Saturday following a wave of punitive strikes in Syria by the United States, Britain and France.
"Trump says, "The nations of the world can be judged by the friends they keep".
Speaking via satellite link to his supporters in Beirut Friday, Nasrallah called the alleged chemical weapons attack in Douma "theater".
Public anger and objections to Iran's presence in Syria, and people's frustration with a collapsing economy, turned into protests in January.
Trump has signaled in recent weeks that, despite advice from his national security team, he wanted to accelerate the timetable of the withdrawal of American forces.
The Trump administration sought to prebut claims from such allies after launching about 120 missiles Friday at three targets in Syria associated with the government's chemical weapons efforts.
"This is the first time as prime minister that I have had to take the decision to commit our armed forces in combat - and it is not a decision I have taken lightly", she said. Officials also said the strike was larger than a similar attack on the Assad regime launched previous year. Syrian government has strongly denied the allegations.
An official says in a statement Saturday that President Donald Trump made clear a year ago that the use of chemical weapons was a red line not to be crossed.
The official spoke anonymously according to protocol.
"Incontrovertibly, the US and its allies are responsible and should be held accountable for the consequences of this adventurism both in the region and beyond", it said. He's also going to hold the Russians and the Iranians who are propping up this regime responsible.
The Iranian drone is eerily similar to a United States drone that Iran captured in 2011.
For Steven Bucci, a former senior Pentagon official and a visiting fellow at the Heritage Foundation, a Washington-based think tank, the US president was "sending a message that this isn't just firing and forgetting and everyone drives home".
The Iranian-backed Hezbollah guerrilla organization immediately published a denial on its Arabic-language affiliate Al-Manar news outlet, saying there was "no truth to the rumor" there had been an Israeli attack.