"It is no longer such that the United States simply protects us, but Europe must take its destiny in its own hands, that's the task of the future", Merkel said during a speech in honor of Macron, according to The Hill.
Merkel made a similar appeal a year ago, following visits by President Donald Trump to her country and the North Atlantic Treaty Organisation alliance in neighboring Belgium. It's her latest retort to Trump, who this week withdrew the US from a nuclear accord with Iran that European powers say they will uphold.
"I had the chance to tell President (Hassan) Rouhani that just now", he said, referring to a phone call earlier with the Iranian leader.
This statement comes a day after Israel attacked multiple Iranian military targets in Syria in response to a failed attempt to fire missiles into Israeli territory.
The Chancellor noted that "on Europe's doorstep" there are many major global conflicts and expressed concern about the risk of war between Israel and Iran in Syria.
Both Macron and Merkel spoke with Trump about maintaining the deal in the weeks leading up to his announcement, even going so far as to lay out a four-point plan for restructuring the agreement as Trump said he wished to do.
Le Maire pointed out that the withdrawal gives European firms doing business in Iran the "very short time of six months" to wind up investments - or risk U.S. sanctions.
The French President has pushed an agenda of huge Eurozone changes since taking charge of Paris in May 2017 - including introducing a European minister for finance, a separate Eurozone budget and parliament.
"We need to choose, build, speak with all so as to construct our own sovereignty that will be the guarantor of stability in (the Middle East), stressed Macron". "Other powers. haven't kept their word", he added, without specifying the powerful countries he was referring to.
Germany, France and Britain are planning a foreign ministerial meeting with Iran to discuss how to respond to the recent developments in the Middle East.
"There are areas beyond the (nuclear) accord that we must talk about", she said.