Germany boss Joachim Low said it was a "close" decision to select Bayer Leverkusen midfielder Julian Brandt ahead of Sane.
However, the 22-year-old is not the only top player who won't be heading to Russian Federation this summer.
Of course, that adventure and "Road to the World Cup" unfortunately didn't last long for the former Schalke man.
The 58-year-old, who has been in charge of Germany since 2006 and won football's biggest showpiece with Die Mannschaft in 2014, opted to omit Sane from his final selection for Russian Federation, despite the winger being named the PFA Young Player of the Season in England.
'That was a very close decision between him and Julian Brandt, which was made in favour of Brandt, ' Low said.
"I'm obviously disappointed I won't participate in the World Cup", he wrote.
Also omitted are Bayer Leverkusen duo Bernd Leno and Jonathan, as well as Freiburg striker Nils Petersen.
While pundits and fans alike expressed their utter shock at Sane's snub, one player who can relate better than anyone, Landon Donovan, offered Sane an alternative to Russian Federation 2018.
His worldwide form, however, is much poorer - he's only provided one assist and is yet to score following 12 appearances with the national side.
Germany are slotted in the Group F of the FIFA World Cup and will face Mexico on 17 June in their tournament opener before locking horns with Sweden and South Korea.