Sergio Romero, Antonio Valencia, Marcos Rojo and Diogo Dalot are also out through injury but Fred should make his Premier League debut in midfield.
"We have only seen him when he has appeared in front of the TV cameras this summer and heard what he has told the media, and I suspect he will behave very differently on the training ground with his players. He is an example of the type of players we need to sign to win trophies and compete at the highest level", Sanchez said.
With United's reported interest in bringing the Brazilian global to Old Trafford, Willian has spoken to reporters about the influence Mourinho has had on his career, admitting the former Chelsea boss is the best manager he has ever worked with.
Manchester United fans have raised questions over Jose Mourinho's transfer activity of late, with a distinct lack of marquee signings being the main cause of concern, but surely a GoFundMe page to raise millions is a little too far.
Jose Mourinho has taken aim at Manchester United's critics on the eve of the new English Premier League soccer season. They [Manchester City] have been playing some great football.
Leicester looked startled by United's early intensity but began to fell their way into the match as debutant James Maddison impressed and their wide men made in-roads.
It leaves Mourinho to start the season with a squad broadly similar to the one which finished 19 points behind City last season, but he insists he is not as disappointed with options as some may think.
His inability to truly imprint his influence on the match was illustrated, more than anything else, by the fact that the Chilean gave away possession more than any other Manchester United player on the night.