"It has to be a motivation, not a pressure, that's the way we take it and hopefully we can improve on what we did the last two seasons because we came up short".
"Up to now the preparation has been completely normal, the difference tomorrow is obviously there are some rules that we will respect", Arteta said.
"Everybody knows I'm a United supporter".
City did pull a goal back minutes later, as Bernado Silva handed his side a life-line with a cool finish from close range after being picked out by Leroy Sane.
"They were very aware of Lyon's strengths and weaknesses and I'm telling you they were prepared", he said.
The Manchester club faces Cardiff City next on Saturday.
"The second half we tweaked a few things to try to control better the counters and have an extra man in midfield and I think we created the chances but we couldn't get back in the game and at this level it's not good enough".
"It has to be Real Madrid [as favourites], they have something special in this competition", he said.
However, the former Arsenal midfielder insists there is far more to what City are building in trying to win the European Cup for the first time than simply spending hundreds of millions in assembling one of the strongest squads in the competition.
But I think it is a very open Champions League - like it was last season but it will be again.
Asked if the atmosphere contributed to City's downfall, Arteta said: "I wouldn't use that as an excuse". "We had this type of crowd in the Champions League before and we were able to win the game".