It is six games since Barca last kept a clean sheet - a 4-0 rout of PSV Eindhoven in their Champions League opener - and the defence has come under scrutiny amid the poor run.
But that doesn't mean Messi will not be in the Nou Camp.
There are alternatives to Messi, with Ousmane Dembele the obvious replacement, although the French winger has suffered a drop in form after a positive start to the campaign and was on the receiving end of some boos from the crowd after replacing the Argentinian on Saturday.
Jidonu Mauyon is a football enthusiast from Nigeria, who writes for a lot of publications, including the likes of Sportainment, Cube Soccer, Give Me Sport, FootballXtra, and Sportskeeda. Two more Madrid defeats followed to leave Lopetegui on the brink while Barca are now 10 points from 12 and top of the table.
The absence of Lionel Messi, out for three weeks with a fractured arm, dominated all the talk - pre-match, post-match and in the stands.
"I lived it with my children and we had a great time with that treble, and also seeing the elimination of Barcelona".
The staff have the support of the players and they will do their best for them on the pitch as well as for Perez's whose project is in threat.
Jordi Alba added a late second to ensure the scoreline reflected Barcelona's dominance and, although Messi will not be fit to face Madrid, Rafinha says his team are in good shape. FC Barcelona is located in the city of Barcelona, the Catalan capital, while Real Madrid is a team from Madrid, the capital of Spain, and they are more than 300 miles apart.
"They were strong and very aggressive in the first half and we didn't use the ball in the right way, if we'd managed possession better we could have hurt them". You will be able to watch all the action and build up to El Clasico on Sunday the 28th of October with beIN SPORTS CONNECT.