Lionel Messi is expected to be out for three weeks with a fractured right arm but his last contribution was to help send Barcelona back to the top of LaLiga on Saturday.
It was a costly victory, though, as Lionel Messi badly bent his right elbow as he crumpled down to the ground in a heap after running into the back of a Sevilla defender.
Some fans went as far as saying the Argentinean was the best player in the match despite featuring for just 18-minutes on the pitch.
"We must prepare ourselves and have resources to cope without him, even if there are tough game".
The three-week injury assessment means Messi will likely return in time for the club's clash with Atletico Madrid at the end of November, which follows an global break. We have the players to cover for him, but we have some very tough games coming up.
Real Madrid have under-performed under new manager Julen Lopetegui.
Champions Barcelona play at home to second-placed Sevilla later today.
Before the clasico, Madrid hosts Viktoria Plzen on Tuesday in the Champions League to try to rebound from a 1-0 loss at CSKA Moscow.
Valencia couldn't manage more than 1-1 against struggling Leganes at home, being held winless for the fifth time in six matches.
Ernesto Valverde's men pushed for more goals in the second half and they were rewarded after the hour when Luis Suarez won a penalty.