The World Cup victor missed his side's Champions League opener, as they let slip a one-goal advantage in the closing stages to lose 2-1 to Inter in Milan.
"It's a good chance to win and focus on ourselves, maybe there's some pressure, but we want to show that people are wrong", Kane said in his pre-match press conference. "As players you want to play against the best in the world and Messi is certainly that, a fantastic player, and we will do our best to stop him".
Last season Tottenham ensured qualification for the knockout stage with a memorable 3-1 win over Real Madrid at Wembley but Pochettino thinks it will be hard to replicate the performance against Barcelona. We need to produce that same energy, the crowd were wonderful that night and if we can get them on their feet as soon as possible, create some chances and take one or two it would put us in a great position.
Harry Kane has spoken of his determination to emulate or better the prolific scoring output of Lionel Messi, as he prepared to face the Barcelona star in the Champions League at Wembley on Wednesday night.
'We are not victims though.
"Messi has set the standard", he added. "We must feel strong", Pochettino told a news conference on Tuesday.
Goalkeeper Hugo Lloris was back in training after a thigh injury but Dele Alli, as expected, was missing with his hamstring problem.
Messi has reportedly responded to Pique by criticizing Barcelona's defence, stating that the side has conceded way too many goals and that the defence needs to do more work.
"The circumstances this season are so tough", said Tottenham manager Pochettino.