Players were hit by shattered glass and thrown objects, and suffered the effects of tear gas and pepper spray used by police to contain the violence.
"The players are all hurt, you can't play this way", Christian Gribaudo, Boca's secretary general, said.
The final of the Copa Libertadores, the equivalent of Europe's Champions League, is finely poised at 2-2 following the first leg at Boca's Bombonera stadium two weeks ago.
Former Manchester United and Manchester City striker Carlos Tevez was amongst those worst affected, and could be seen in clear discomfort as he was escorted inside to the dressing room.
Kickoff was initially delayed for an hour; then for another 20 minutes; then another 55.
"We are not in a position to play the game, they are forcing us to play the game", said Tevez.
Boca captain Perez and Gonzalo Lamardo were taken to a nearby clinic.
Footage also showed Nahitan Nandes, Dario Benedetto, Mauro Zarate, Ramon Abila, and Agustin Almendra among the injured. His colleagues, even with time to recover from the effects of ingesting a toxic substance, could not possibly have been at their psychological peak for what is nearly certainly the biggest game they will ever play and the biggest game in the history of South American club football.
CONMEBOL executives met with Federation Internationale de Football Association president Gianni Infantino, who came to Buenos Aires to attend the match, for a final call on whether the final should proceed or not.
Tournament organisers Conmebol, the South American football governing body, said the match at River's Monumental stadium between the local arch rivals would kick-off at 7.15pm (2215 GMT), more than two hours after its scheduled start time.
At time of writing - a little after 9pm - the match still hasn't kicked off due to wild scenes at River Plate's Estadio Monumental in Buenos Aires. However, it does now seem likely that the match will be suspended and take place at a later date. No visiting fans are allowed in the stadium, following a 2013 ban on away fans to stop football related violence in Argentina. Had River won, Boca would surely have appealed against the result and in the circumstances, it would have been hard for anybody to concentrate on the actual game.
Boca and River drew the first leg 2-2 on November 11, a game that was delayed 24 hours itself because of a waterlogged pitch at Boca's stadium.
This local encounter is widely viewed as the fiercest rivalry in world football.